Location:
Faculty Hall
Dear All,
*CBR LECTURE SERIES*
Centre for Brain Research (CBR), IISc
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Speaker:
Dr. K. Thangaraj
Chief Scientist and Group Leader
Centre for Cellular and Molecular Biology, Hyderabad, India
Date: May 31, 2018 Time: 4.00 PM TEA/COFFEE: 5.00 PM
Venue: Faculty Hall, IISc
Title: Human origin, health and disease: Genomic perspectives
Abstract:
India represents one of the largest sources of human diversity, comprising of more than four and half thousand anthropologically well-defined populations. Most of them are endogamous (marrying within a population) communities with significant barriers to gene flow due to sociological, linguistic and cultural factors that restrict inter-population marriage. This has resulted in high Fst (population specific difference) and genetic drift. To assess the impact of endogamy, we have analysed 2,800 individuals from over 275 distinct South Asian groups from India, Pakistan, Nepal, Sri Lanka, and Bangladesh using about 600,000 genome-wide markers. We found that 81 out of 263 unique South Asian groups, including 14 groups with estimated census sizes of over a million, have a strong founder event than the one that occurred in both Finns and Ashkenazi Jews in the West – these are founder groups known to have large numbers of recessive diseases. We identified multiple examples of recessive diseases in Indian subcontinent that are the result of such founder events. Our study provides opportunity for discovering population-specific disease causing genes in communities known to have strong founder events. Mapping of mutations that are responsible for population-specific disease would help in developing strategies for diagnosis, counseling, management and modifying the clinical course of these disorders and to reduce the disease burden among South Asians.
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***All are cordially invited ***
